GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4794202 | 1 | rs4794202 | chr17:45930539 | SCRN2 | chr17:45915049-45918699:- | -0.28 | -6.2 | 1.22E-9 | Alzheimer's disease (cognitive decline) |
| THCA | cis | rs477692 | 1 | rs479478 | chr10:131428959 | MGMT | chr10:131265454-131565783:+ | 0.38 | 11.35 | 1.29E-26 | Response to temozolomide |
| THCA | cis | rs8078723 | 1 | rs4794823 | chr17:38166265 | GSDMA | chr17:38119226-38134019:+ | -0.31 | -7.25 | 1.71E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs8078723 | 1 | rs4794824 | chr17:38179290 | GSDMA | chr17:38119226-38134019:+ | -0.33 | -7.58 | 1.87E-13 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs6686842 | 1 | rs479493 | chr1:41567202 | SCMH1 | chr1:41492875-41707788:- | 0.2 | 4.7 | 3.35E-6 | Height |
| THCA | cis | rs8078723 | 1 | rs4795412 | chr17:38150604 | GSDMA | chr17:38119226-38134019:+ | -0.32 | -7.26 | 1.6E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs8078723 | 1 | rs4795412 | chr17:38150604 | ORMDL3 | chr17:38077296-38083854:- | 0.14 | 3.41 | 0.000702 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs8078723 | 1 | rs4795415 | chr17:38157995 | GSDMA | chr17:38119226-38134019:+ | -0.32 | -7.28 | 1.39E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs8078723 | 1 | rs4795416 | chr17:38158133 | GSDMA | chr17:38119226-38134019:+ | -0.32 | -7.28 | 1.39E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs8078723 | 1 | rs4795418 | chr17:38164851 | GSDMA | chr17:38119226-38134019:+ | -0.31 | -7.25 | 1.71E-12 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | ANKRD13B | chr17:27916801-27941778:+ | -0.36 | -8.84 | 1.85E-17 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | CORO6 | chr17:27941774-27948441:- | -0.51 | -11.74 | 4.02E-28 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | EFCAB5 | chr17:28256874-28435469:+ | -0.6 | -11.33 | 1.63E-26 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | GIT1 | chr17:27900487-27916610:- | -0.29 | -6.79 | 3.24E-11 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4795525 | chr17:28388487 | LRRC37B2 | chr17:28903483-28992715:+ | -0.18 | -3.94 | 9.28E-5 | Coffee consumption (cups per day) |